The Bluebirds travel to Bournemouth, the Whites welcome London rivals Crystal Palace and Nuno's runaway Championship winners face Everton at Molineux.
Liverpool to be first opponents at Tottenham’s new stadium
"Wembley was great for us last season and we are even more used to that than we are the new stadium".
And the Spaniard has been given a testing opening to Premier League management.
Premier League pedigree and Champions League experience should make up for the Three Lions' youthfulness, said the Manchester United boss, who has seen four of his Reds picked for the side.
Although all fixtures dates are subject to change due to the requirements of broadcasters, the release of the Premier League schedule for the 2018-19 campaign enables managers, players and supporters to plot their club's route to success, whether it be a title push or battle for survival. Tottenham make the trip to Tyneside to play Newcastle United, while Chelsea go to Huddersfield and Manchester United host Leicester City.
Liverpool begin their season at home to West Ham United, with Manuel Pellegrini taking charge of the Hammers for the first time.
Four rounds of Premier League fixtures are scheduled to be played before the first worldwide break, which is over the weekend of 8 and 9 September.
England face Tunisia in their opening game on Monday, with Panama and star-studded Belgium their other opponents in Group G.