"I really feel for John", added Anderson, who has now made his second final at a Slam after finishing runner-up to Nadal at last year's US Open.Anderson finished the match with 49 aces and 118 winners; Isner had 53 aces and 129 winners. "This kind of match you live for, you work for". Fortunately, he was at the end of the court farthest from the Royal Box, where the pair of visiting Duchesses, Kate and the newly married Meghan, sat in the front row.
"It's hard to pick the words, I'm just going through things, the flashbacks and everything I've been through to get here, to get to finals, to win against the best player in the world", he told BBC Sport. I know, as everything in life, we are evolving.
Isner, 33, stands 6ft 10in and come the final points he looked nearly too tired to move for the ball.
With that three-day epic being just a first round contest, when Isner returned for his next match, he folded very, very quickly - in just 75 minutes and without an ace in sight.
He believes his semi-final should have been played before the Anderson-Isner match on Friday. Moments later, he got to love-40 before Nadal took five points in a row to serve out the set.
Nadal and Djokovic regularly - and spectacularly - ran down shots to force long rallies, drawing gasps and cheers from the appreciative crowd.
Two hours and two sets in, they were even at one apiece, each via tiebreaker, with zero service breaks, only the very occasional extended point and aces by the dozen.
Djokovic has a 5-1 edge against Anderson, including a 2-0 record against the South African at Wimbledon.
Nadal faced a break point at 4-3 behind but roared away from trouble with a powerful first serve followed by two vicious, whipped forehand winners.
Anderson triumphed 7-6 (8/6), 6-7 (5/7), 6-7 (9/11), 6-4, 26-24 in the second longest Grand Slam match ever played.
The atmosphere, in sharp contrast to Friday's slug-fest, was electric.
Numerous best points came in the tiebreaker, including a 23-shot rally that Nadal finished off with a forehand half-volley drop shot to set up his first set point.
Again Djokovic resisted, and again at 8-7 down. "I'm a different person, different player today", Djokovic said.
Of the task against Anderson, Djokovic said: "Hopefully we can first of all play, both of us get out on court". It's been a roller-coaster for him in the last couple of rounds but he had a day off and that means a lot. I wish I could have had one.
It wasn't enough, though, and Rafa found a way to advance to his first Wimbledon semi-final since 2011. "I'm trying to digest that first, enjoy it, and we'll think about the next one".
"It was really tough for both of us. I'm going to have to recover as much as I can and to try to be as ready, as fresh as possible".