City have been dealt a major injury blow with the news that Kevin de Bruyne has been ruled out for three months with a knee ligament injury while second-choice goalkeeper Claudio Bravo is facing six months out after rupturing an Achilles tendon.
It gets no easier for Nuno Espirito Santo and his men on Saturday when the champions are in town.
Last season's Premier League Young Player of the Year was one of the few City first-team players not to play at the World Cup after being surprisingly omitted from the Germany squad.
Although Wolves were in a different division to their opponents last season they did take on the Citizens, when the two sides did battle in the Carabao Cup at the Etihad Stadium.
Former Manchester United defender Neville hinted that Manchester City are in pole position to retain their Premier League crown.
Highlights of the 1-1 draw between Wolves and Manchester City in the Premier League.
Peter Whittingham is in danger of becoming a quiz answer - the last Cardiff player to score in the Premier League. The player is also Wolves' record signing, who came on at half-time against Leicester and could make his full debut against City.
The frightening juggernaut of Manchester City was finally given a reality check by newly-promoted Wolverhampton Wanderers on Saturday.
Manchester City's ideal start to their Premier League title defence was ended with a 1-1 draw at newcomers Wolverhampton Wanderers on Saturday while Arsenal earned the first win under Unai Emery, a 3-1 victory over West Ham United.
"The second team wasn't a proper competition for him previous year; that's why he went to Holland to play the big teams".
Teams like Burnley, Swansea, Watford, Hull and Everton have proved incredibly resolute and frustrating in the last few seasons, and have prevented Liverpool from breaking them down in the way that we are so accustomed to seeing the Reds do.
While the opening goal did not come directly from a Wolves counter, it did come from the corner that resulted in the home side breaking behind an over-committed Manchester City.