It has been a troubled start to the season, but United come into this game on the back of successive Premier League wins over Burnley and Watford.
But Mourinho has revealed Antonio Valencia will not feature because there is no point in risking his knee on the pitch. "But we know that a big club with a great coach is playing against us".
The Portuguese picks David de Gea in goal, while in defence he names Diogo Dalot in defence, along with Chris Smalling, Victor Lindelof and Luke Shaw.
In-form striker Romelu Lukaku, who scored a hat-trick against BSC Young Boys three years ago for Everton, will spearhead the attack for Manchester United. Everyone knows he has a favourite surface, but he has to win on the surfaces he is not in love with.
Jose Mourinho's last European campaign ended in misery as his side lost 1-2 at home to Sevilla in the round of 16.
Marouane Fellaini. The much-maligned midfielder played the full 90 minutes in both wins and he is proving to be the most effective, and perhaps most important, player in Mourinho's armoury. I think there's a balance in the middle and think that Mourinho in developing a player you have to take responsibility of how they develop.
United has some momentum going after consecutive wins in the Premier League, and the team will impose its will here by dominating possession, creating a flurry chances and putting three of them away.
"Try to be a little bit happy with the ones that are playing and not to be greedy with the ones that are not playing".
"By experience, when a team reaches the quarterfinals then even the teams that are not favourites, when you arrive in the quarterfinals you smell the distance is not very far and every team starts thinking about it, but is too early now", he said.
"So, we have (Romelu) Lukaku, Rashford, (Juan) Mata, Alexis (Sanchez), (Anthony) Martial and they can not play all together".