The Portuguese full-back finally got his first appearance for the senior side as United beat BSC Young Boys in the Champions League on Wednesday.
"But I think it's going to be a very hard season, not just for us, also for the others because the others they can say exactly the same as I am saying".
"I want him in this process of adaptation to play totally fresh, so he's not playing [against Wolves], he plays Tuesday [against Derby in the Carabao Cup]", Mourinho told a news conference on Friday.
Jose Mourinho has said three straight wins has not changed his opinion that Manchester United are in for a tough season.
Mourinho believes his team will be better this campaign than they were last, when they finished a distant second to Manchester City.
"I think the team as a team is resolving the defensive problems better than before", Mourinho said.
Pressed on whether the 29-year-old needed to raise his game.
"I am optimistic, but it will be a hard season, yes", he said.
"A team that yesterday looked very bad, today looks very good and yesterday looked very good, today looks very bad. He plays Tuesday again", Mourinho was quoted as saying by the Mirror.
Macari has been left impressed with the quality of football the team from the Black Country have displayed this season and admits that they deserved more than just a 1-0 win over Burnley last weekend.