With Kevin De Bruyne unlikely to return straight to the starting lineup the onus will remain on the Spaniard to keep City ticking, and the former England global is likely to be given the task of stopping him.
Neville's colleague at Sky Sports, Jamie Carragher, says that Liverpool can not afford to lose to City if they want to mount a serious title challenge.
Liverpool's ability to get the better of Guardiola's tactics in recent meetings comes from an aggressive approach which limits the control City have on dominating key positions, and Milner will be vital in stopping their creative hub in Silva.
The only issue is unlike last season, Liverpool won't have a player like Oxlade-Chamberlain who can test the City defence with his driving runs from midfield.
Liverpool face their biggest game of the season so far this weekend, with City heading to Anfield for a top-of-the-table Premier League clash. It's not that you go out of a game like this thinking now we have the solution to deal with Manchester City. After strengthening significantly in the summer, the expectation will be on Liverpool in getting a result with the hope of reclaiming the league title for the first time since the 89/90 season. "But that depends on the Liverpool people, not on Manchester City". They are right. So we won the Premier League. "We don't make it bigger - we just know it is big, it matters and we prepare for it accordingly".
Almost half of all City's defeats last season came against Klopp's team, including both legs of their Champions League quarter-final, while a 4-3 loss at Anfield ended their hopes of going a whole Premier League season unbeaten.
Defender Walker added: "We're the champions and we have a point to prove".
"I was surprised the front three were playing". "The Police knew it before it happened, now we know it, I don't know whats going to happen".
He said: "Obviously we won the last three games against City". Adam Lallana and Divock Origi are a couple of other players who won't be taking part in the game. Look at the game at Manchester City - there was an offside goal, which was not offside, which could have changed the game, but we were really calm.
"There is no real way, no one thing that you have to do".