The suspect has been charged with five crimes, including illegal mailing of explosives.
Sayoc is accused of sending 14 bombs through the U.S. Mail to President Barack Obama, former Secretary of State Hillary Clinton, ex-Vice President Biden, Democratic Party backer George Soros, actor Robert De Niro and others.
An earlier package had been sent to former Obama CIA Director John Brennan in care of CNN in NY.
Sayoc is being prosecuted in NY, so his Florida hearing will likely be brief and process-oriented.
Sayoc, who seemed to be living out of a van in Aventura, Florida, was taken into custody on a day when four more explosive packages were found, including two intended for U.S. senators, both Democrats.
Sayoc, a registered Republican with a criminal history, now faces up to 48 years in prison, although further charges are expected to be filed against him for the mail-bombing campaign, which heightened political tensions and put the country on edge.
The FBI confirmed the Booker-directed package in a tweet, saying the new package was "similar in appearance" to others directed at former government officials and others over the past few days that have contained explosive devices. Soros has called Trump's presidency "dangerous".
A registered Republican, Sayoc's political views were evident on social media, railing against Democrats, Muslims and liberals in Facebook and Twitter posts.
Sayoc targeted individuals who'd been bashed by the president, the packages and his van plastered with pro-Trump, anti-left and anti-media messages all indicating he was politically motivated.
Fingerprint and DNA evidence helped identify the suspect, officials said, but they were uncertain if additional bombs were made.
The bombs were sent in manila envelopes lined with bubble wrap and consisted of plastic 6-inch pipes packed with explosive material and wired to small clocks and batteries, a criminal complaint filed in federal court in Manhattan said. A package surfaced on Monday near his home in Katonah, New York.
He nearly certainly had no idea that lab technicians had linked DNA on two pipe bomb packages he was accused of sending to prominent Democrats to a sample previously collected by Florida state authorities. The Secret Service said neither package reached its intended recipient.
Thankfully, as none of the explosive devices ended up going off and no one was hurt, people were able to make jokes about the ridiculous van, and the most popular meme on Twitter seems to be comparing it to a awful ice cream truck.