He could face life behind bars in a maximum security US prison.
NY jurors, whose identities were kept secret, deliberated for six days, sorting through piles of evidence gathered since the 1980s that Guzman's drug cartel smuggled tons of cocaine, heroin, methamphetamine and marijuana into the US.
Read the full report at the New York Post.
Guzman spoke in the courtroom only once during the trial, saying he would not testify in his own defense, NBC News reported.
Jurors in federal court in Brooklyn convicted Guzman, 61, head of the Sinaloa Cartel, on all 10 counts brought by USA prosecutors.
The tension at times was cut by some of the trial's sideshows, such as the sight of Guzman and his wife, Emma Coronel Aispuro, showing up in matching burgundy velvet blazers in a gesture of solidarity. Guzman smiled and waved, and she touched her hand to her chest.
The notorious former leader of the dreaded Sinaloa Cartel has been the subject of numerous TV shows and films, including Univision's series El Chapo, a recent Netflix documentary with the same title that was ridiculed by Sean Penn, Netflix's Narcos: Mexico and documentary The Day I Met El Chapo with Kate del Castillo.
Guzman's lawyers did not deny the defendant's charges but argued that he was the victim of government witnesses who were worse than he was. "We were faced with extraordinary and unprecedented obstacles in defending Joaquin, including his detention in solitary confinement", the statement said, Reuters reported.
President Andres Manuel Lopez Obrador was elected previous year after promising a change to the deadly military-led war against drug gangs, suggesting a negotiated peace and amnesty for non-violent drug dealers, traffickers and farmers. President Andrés Manuel López Obrador was elected a year ago after promising a change, suggesting a negotiated peace and amnesty for non-violent drug dealers, traffickers, and farmers.
He added: "There are those who say the war on drugs is not worth fighting".
The prosecution's case against Guzman, whose nickname translates to "Shorty", included the testimony of several turncoats and other witnesses.
The cartel boss, who infamously escaped from jail twice, ran a global drug empire and had amassed a fortune of billions of dollars. She said Guzman led her to a trap door beneath a bathtub that opened up to a tunnel that allowed them to escape.