United produced a miracle to win at Paris Saint-Germain in the previous round and in Europe this season they have been much stronger on the road. "The league is our objective and the Champions (League) would be a dream".
Barca's imperious domestic record is in stark contrast to their recent failures in the Champions League, where they have failed to get beyond the quarter-finals since winning the competition in 2015.
The 19-year-old has also broken into the Italy team this year, scoring in back-to-back EURO 2020 qualifiers during March's global break.
Midfielder Arturo Vidal, who did start the game, said Barca's players had been distracted by Tuesday's game against United.
'We don't want them to score but our game plan as always will be to try to score, anything else would be absurd'.
"(Pique) is as committed to the team as he ever has been, but at an incredibly high level", said coach Ernesto Valverde last week.
There was a caveat to Valverde's talk of past United glory at the Camp Nou.
Kevin-Prince Boateng shot over as Barcelona began to take control, but clear chances were few and far between in the opening half-hour.
"Of course the PSG performance gives us hope and belief we can do it, but we know we are playing against probably the favorites for the tournament", said Solskjaer.
And while we're all well aware of the magic Messi is capable of, he proved his toughness with his determination to play on after losing quite a lot of blood. This is 335. These wins have enabled him to capture 7 of the 10 league titles.
Munir El Haddadi, Pablo Sarabia and Franco Vazquez scored as Sevilla went 3-1 ahead but a superb strike from a free kick by Cristian Tello with eight minutes remaining kept the result in doubt until the final whistle.